Scientist I – Optical Physiology of Neural Computation

The mission of the Allen Institute is to unlock the complexities of bioscience and advance our knowledge to improve human health. Using an open science, multi-scale, team-oriented approach, the Allen Institute focuses on accelerating foundational research, developing standards and models, and cultivating new ideas to make a broad, transformational impact on science.

The mission of the Allen Institute for Neural Dynamics is to answer fundamental questions about brain function. Specifically, how does our brain build our understanding of the complex world around us to guide the flexible behaviors that address our biological needs? The answers will be in terms of defined neuron types interacting across the whole brain and body, requiring us to develop next-generation neurotechnologies and employ a team-based approach for discovery neuroscience. Knowledge, data, and tools will be widely shared, in part to support the development of therapies for brain disorders.

We seek a skilled neuroscientist / biophysicist to design and perform experiments using optical methods to study how neurons compute. Using genetically encoded fluorescent indicators of neurotransmitter inputs and firing output, we seek to study input-output operations of individual neurons in behaving mice. The ideal candidate will be team-oriented, have deep knowledge in biophysics and neuroscience, and have an interest in cutting-edge instrumentation. This position is part of the Institute’s Optical Physiology Group, and will make use of state-of-the-art microscopes, genetic tools, and anatomy capabilities developed at the Institute.

The Allen Institute believes that team science significantly benefits from the participation of diverse voices, experiences, and backgrounds. Progress in science benefits from multiple perspectives. We are committed to increasing diversity across every team and encourage people from all backgrounds to apply for this role.

Essential Functions

• Design and conduct experiments to study learning and computation in cortical neurons in vivo
• Perform optical physiology experiments in vivo using complex instrumentation and fluorescent indicators
• Participate in multidisciplinary studies involving in vivo fluorescence imaging, mouse behavior, molecular anatomy, and data-driven modeling
• Train team members to perform procedures
• Collaborate with theorists to analyze data and develop models
• Present results internally, via talks and progress reports, and to the external community, via conferences and publications

Note: Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions. This description reflects management’s assignment of essential functions; it does not proscribe or restrict the tasks that may be assigned.

Required Education and Experience

• PhD in neuroscience, biochemistry, biophysics, physics, biomedical engineering, or related field; or equivalent combination of degree and experience

Preferred Education and Experience

• 0 - 5 years of postdoctoral experience
• Ability to write high-quality, reusable code in Python or Julia
• Demonstrated interest in conducting multidisciplinary and collaborative research
• Experience with in vivo brain imaging and/or electrophysiology
• Familiarity with modern software development best practices (e.g. git)
• Working knowledge of computational statistics and data science
• Excellent written and verbal communication skills
• Strong publication record

Work Environment

• May enter laboratory environment, including potential exposure to lasers, biohazards

Physical Demands

• Fine motor movements in fingers/hands to operate computers and other office equipment; repetitive motion with lab equipment
• Stooping, bending, crouching
• Reaching, or climbing ladders

Position Type/Expected Hours of Work

• This role is currently working onsite and is expected to work onsite for the majority of working hours. The primary work location for this role is Allen Institute campus, with flexibility to work remotely on a limited basis. We are a Washington State employer; any remote work must be performed in Washington State.

Travel

• Attendance and participation in national and international conferences required

Additional Comments

• **Please note, this opportunity offers relocation assistance**
• **Please note, this opportunity offers work visa sponsorship**

Annualized Salary Range

• $77,250 - $103,000 *

* Final salary depends on required education for the role, experience, and level of skills relevant to the role, along with work location, where applicable.

Benefits

• Employees (and their families) are eligible to enroll in benefits per eligibility rules outlined in the Allen Institute’s Benefits Guide. These benefits include medical, dental, vision, and basic life insurance. Employees are also eligible to enroll in the Allen Institute’s 401k plan. Paid time off is also available as outlined in the Allen Institute's Benefits Guide. Details on the Allen Institute’s benefits offering are located at the following link to the Benefits Guide: https://alleninstitute.org/careers/benefits.

It is the policy of the Allen Institute to provide equal employment opportunity (EEO) to all persons regardless of age, color, national origin, citizenship status, physical or mental disability, race, religion, creed, gender, sex, sexual orientation, gender identity and/or expression, genetic information, marital status, status with regard to public assistance, veteran status, or any other characteristic protected by federal, state or local law. In addition, the Allen Institute will provide reasonable accommodations for qualified individuals with disabilities.