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Scientist I Ė Vector Engineering for Parkinsonís Disease

Department: Human Cell Types

Scientist I Ė Vector Engineering for Parkinsonís Disease - Human Cell Types

 

The mission of the Allen Institute is to unlock the complexities of bioscience and advance our knowledge to improve human health. Using an open science, multi-scale, team-oriented approach, the Allen Institute focuses on accelerating foundational research, developing standards and models, and cultivating new ideas to make a broad, transformational impact on science.

The mission of the Allen Institute for Brain Science is to accelerate the understanding of how the human brain works in health and disease. Using a big science approach, we generate useful public resources, drive technological and analytical advances, and discover fundamental brain properties through integration of experiments, modeling and theory. We also are interested in transforming technology developed in our basic research divisions into effective therapies for human disease.

We are seeking a scientist to join the Gene Therapy program in the Human Cell Types department (led by Ed Lein). The Gene Therapy program aims to directly apply our enhancer-based AAV technology (see Graybuck, Daigle, et al., Neuron 2021, and Mich et al., Cell Reports 2021) towards new research programs that tackle neurodevelopmental and neurodegenerative diseases.  We are seeking a strong experimentalist to contribute to a newly launched Parkinsonís disease program. The successful candidate will be a strong molecular biologist, experienced in building and optimizing AAVs to achieve expression in the mammalian brain. The successful candidate will also have a background in neurodegenerative research, be an exceptional team player, have excellent communication skills, and thrive in dynamic environments.

The Allen Institute offers exceptional working conditions, and nurtures team science in an intellectually rich and stimulating setting. We provide a highly collaborative research environment offering the opportunity to interface closely with our molecular and cell biologists, bioinformaticians, and partner institutions.

We believe that team science significantly benefits from the participation of diverse voices and backgrounds. High-quality science can only be produced when it includes different perspectives. We are committed to increasing diversity across every team and encourage people from all backgrounds to apply for this role.

Essential Functions

  • Discover enhancer elements for Parkinsonís disease-relevant brain regions and cell types
  • Design and build AAV vectors expressing a variety of therapeutic transgenes
  • Optimize viral vectors to improve expression levels and/or specificity in the brain
  • Deliver AAVs to rodents via different routes (i.e. RO, ICV, ICM, stereotaxic)
  • Design and perform biochemical and histological experiments to evaluate transgene expression in the brain (e.g. western, RNAscope, immunohistochemistry, fluorescence imaging)
  • Analyze and communicate results rapidly and with a high level of transparency
  • Present results internally, externally, and through publications
  • Work effectively in a cross-functional team environment

Note: Reasonable accommodation may be made to enable individuals with disabilities to perform the essential functions. This description reflects managementís assignment of essential functions; it does not proscribe or restrict the tasks that may be assigned.

Required Education and Experience

  • PhD degree in Neuroscience, Molecular Biology, or related field; or equivalent combination of degree and experience

Preferred Education and Experience

  • Strong experience with molecular cloning techniques and gene optimization strategies
  • Strong experience with AAVs and gene delivery approaches
  • Experience with diverse histological (multiplexed FISH, IHC) and imaging (confocal, epifluorescence) techniques in brain tissue
  • Strong desire to develop targeted therapeutics for the treatment of neurodegenerative disorders
  • Knowledgeable about rodent brain neuroanatomy and brain cell types and circuits
  • Able to work at the bench 80% of the time, independently, as well as in a collaborative fast-paced environment
  • Proven independent thinker, nimble, and highly motivated experimentalist
  • Ability to meet aggressive timelines and deliverables in a collaborative environment
  • Excellent organizational and communication skills
  • Experience leading projects and designing experiments
  • Strong publication record

Work Environment

  • Laboratory atmosphere Ė possible exposure to chemical, biological, or other hazardous substances, including biosafety level 2 recombinant viruses.
  • Exposure and handing of laboratory animals

Physical Demands

  • Fine motor movements in fingers/hands to operate computers and other office equipment and lab equipment
  • Frequently required to sit, stand, walk, stoop, kneel or reach
  • Occasional lifting to 30 pounds

Position Type/Expected Hours of Work

  • This role is currently working onsite; due to COVID-19 and our focus on employee safety, we continue to evaluate the safest options for our employees.

Additional Eligibility Qualifications

  • In keeping with our focus on employee safety, all employees must be fully vaccinated against COVID-19 as a condition of employment unless a medical or religious exemption is approved. All employees will be required to keep their vaccination status up to date according to CDC guidance and our policy.

Additional Comments

  • **Please note, this opportunity offers relocation assistance**
  • **Please note, this opportunity offers work visa sponsorship**

 

It is the policy of the Allen Institute to provide equal employment opportunity (EEO) to all persons regardless of age, color, national origin, citizenship status, physical or mental disability, race, religion, creed, gender, sex, sexual orientation, gender identity and/or expression, genetic information, marital status, status with regard to public assistance, veteran status, or any other characteristic protected by federal, state or local law. In addition, the Allen Institute will provide reasonable accommodations for qualified individuals with disabilities.

 

 
 
 
 

 

 
 

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