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Senior Research Associate - Biodistribution of AAV's in Primates for Parkinson's Disease

Department: Human Cell Types

Senior Research Associate Ė Biodistribution of AAVs in Primates for Parkinsonís Disease

 

The mission of the Allen Institute is to unlock the complexities of bioscience and advance our knowledge to improve human health. Using an open science, multi-scale, team-oriented approach, the Allen Institute focuses on accelerating foundational research, developing standards and models, and cultivating new ideas to make a broad, transformational impact on science.

The mission of the Allen Institute for Brain Science is to accelerate the understanding of how the human brain works in health and disease. Using a big science approach, we generate useful public resources, drive technological and analytical advances, and discover fundamental brain properties through integration of experiments, modeling, and theory. We also are interested in transforming technology developed in our basic research divisions into effective therapies for human disease.

We are seeking an experienced research associate to join the Gene Therapy program in the Human Cell Types department (led by Ed Lein). The Gene Therapy program aims to directly apply our enhancer-based AAV technology (see Graybuck, Daigle, et al., Neuron 2021, and Mich et al., Cell Reports 2021) towards new research programs that tackle neurodevelopmental and neurodegenerative diseases.  We are seeking a highly motivated researcher to support non-human primate brain tissue processing, histology, imaging, and data analysis for a newly launched Parkinsonís disease program. The successful candidate will also be an exceptional team player, have excellent communication skills, and thrive in dynamic environments.

The Allen Institute offers exceptional working conditions, and nurtures team science in an intellectually rich and stimulating setting. We provide a highly collaborative research environment offering the opportunity to interface closely with our molecular and cell biologists, bioinformaticians, and partner institutions.

We believe that team science significantly benefits from the participation of diverse voices and backgrounds. High-quality science can only be produced when it includes different perspectives. We are committed to increasing diversity across every team and encourage people from all backgrounds to apply for this role.

Essential Functions

  • Assist with planning and execution of AAV injection experiments in macaques at the Washington National Primate Research Center (WaNPRC)
  • Manage macaque brain tissue collections and tissue processing for recovery of virus injection sites
  • Confirm virus injection sites by Sanger sequencing and perform immunohistochemistry and/or multiplex FISH to validate viral tools and imaging
  • Help analyze virus expression in non-brain tissues
  • Present results frequently to internal stakeholders
  • Uphold rigorous standards, including detailed lab notebook of all experiments
  • Contribute to reports, scientific publications, and grant applications

Note: Reasonable accommodation may be made to enable individuals with disabilities to perform the essential functions. This description reflects managementís assignment of essential functions; it does not proscribe or restrict the tasks that may be assigned.

Required Education and Experience

  • Bachelorís degree in life sciences or other related fields
  • A minimum of 6 years of relevant equivalent work or research experience

Preferred Education and Experience

  • Masterís degree in life sciences or other related fields
  • 7 Ė 10 years of relevant equivalent work or research experience
  • Experience working with macaque brain tissue and with standard histological methods
  • Experience with epifluorescence and confocal microscopy
  • Experience with molecular biology techniques (i.e. qPCR, DNA extraction from tissue, and Sanger sequencing)
  • Able to work at the bench 80% of the time, independently, as well as in a collaborative fast-paced environment
  • Highly motivated researcher with a track record of contributing to research programs
  • Ability to meet aggressive timelines and deliverables in a team-centric environment
  • Excellent organizational and communication skills
  • Proficiency in MS Office programs (i.e. Word, Excel, Powerpoint)

Work Environment

  • Laboratory atmosphere Ė possible exposure to chemical, biological, or other hazardous substances, including biosafety level 2 recombinant viruses.
  • Exposure and handing of laboratory animals
  • Frequently required to sit, stand, walk, stoop, kneel or reach

Physical Demands

  • Fine motor movements in fingers/hands to operate computers and other office equipment and lab equipment
  • Occasional lifting up to 30 pounds

Position Type/Expected Hours of Work

  • This role is currently working onsite; due to COVID-19 and our focus on employee safety we continue to evaluate the safest options for our employees.

Additional Eligibility Qualifications

  • In keeping with our focus on employee safety, all employees must be fully vaccinated against COVID-19 as a condition of employment unless a medical or religious exemption is approved. All employees will be required to keep their vaccination status up to date according to CDC guidance and our policy.

Additional Comments

  • **Please note, this opportunity offers relocation assistance**
  • **Please note, this opportunity offers work visa sponsorship**

 

It is the policy of the Allen Institute to provide equal employment opportunity (EEO) to all persons regardless of age, color, national origin, citizenship status, physical or mental disability, race, religion, creed, gender, sex, sexual orientation, gender identity and/or expression, genetic information, marital status, status with regard to public assistance, veteran status, or any other characteristic protected by federal, state or local law. In addition, the Allen Institute will provide reasonable accommodations for qualified individuals with disabilities.

 

 
 
 
 

 

 
 

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