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Research Associate III Ė Histology - Experimental Immunology

Department: Experimental Immunology

Research Associate III Ė Histology - Experimental Immunology

The mission of the Allen Institute is to unlock the complexities of bioscience and advance our knowledge to improve human health. Using an open science, multi-scale, team-oriented approach, the Allen Institute focuses on accelerating foundational research, developing standards and models, and cultivating new ideas to make a broad, transformational impact on science.

The mission of the Allen Institute for Immunology is to advance the fundamental understanding of human immunology through the study of immune health and diseases where excessive or impaired immune responses drive pathological processes. The Institute will employ a multi-disciplinary team approach in collaboration with academic centers of human immunology to generate novel mechanistic insights into the immune synapse in health and in diseases such as autoimmunity or oncology. The Institute will simultaneously provide a foundational data set and tools for future immunological research as well as a novel collaboration portal for the broader scientific community.

The Allen Institute for Immunology is seeking a Research Associate III (RA-III) to join a team focused on investigating human immune responses in health and disease. We are utilizing a multi-omic approach to comprehensively evaluate the immune system in the setting of autoimmunity, cancer, and infection. The RA-III will work with multi-disciplinary team but will focus on sectioning of various tissues stored as frozen, fixed, and FFPE specimens. They will develop tissue staining approaches to interrogate immune cell infiltrates into tissues and will work with a team establishing spatial, tissue-based transcriptomics for evaluating the activation state of immune cell infiltrates into human tissues. Expertise in other techniques is also considered an advantage including immune cell functional assays, cell culture systems, flow cytometry assays, etc. Opportunities exist for the exceptional candidate to actively contribute to the analysis and interpretation of data from these studies.

The Research Associate III is an advanced position responsible for executing a wide variety of laboratory tasks and/or experiments in a high-quality production environment following Standard Operating Procedures (SOPs). A successful candidate possesses excellent attention to detail and eagerness to work effectively in a Team Science, deadline-driven atmosphere.

The Allen Institute believes that team science significantly benefits from the participation of diverse voices, experiences, and backgrounds. High-quality science can only be produced when it includes different perspectives. We are committed to increasing diversity across every team and encourage people from all backgrounds to apply for this role.

Essential Functions

  • Cryosectioning and microtome sectioning of various tissues including but not limited to Synovium, skin, gut, lung mucosa, lymph nodes, spleen, and bone marrow
  • Perform multiple histological staining processes (Nissl, IHC, Biocytin, ISH)
  • Operate complex instrumentation (Tecan, Autostainers/coverslipper, etc.)
  • Reagent prep (ACSF, PFA, etc.)
  • Manual and automated cover-slipping
  • Compliance with SOPs, good laboratory practices, and regulatory requirements
  • Maintain accurate laboratory documentation using established methods (which may include Microsoft or Google Software packages including document, spreadsheet, or slide preparation, custom Laboratory Information Management Systems (LIMS) and others
  • Follow detailed instructions in execution of laboratory tasks
  • Maintain clear and accurate communication within and between teams
  • Collaborate and work efficiently in a team environment
  • Maintain high quality standards
  • Complete routine tasks with minimal supervision
  • Adhere to a team schedule and individual time management
  • Multi-task as needed
  • Other duties as assigned

Note: Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions. This description reflects managementís assignment of essential functions; it does not proscribe or restrict the tasks that may be assigned.

Required Education and Experience

  • Bachelorís degree in a life science field
  • 4 years of relevant post-undergraduate laboratory research experience

Preferred Education and Experience

  • Masterís degree or equivalent combination of education and experience
  • Background in Immunology with a working knowledge of immune cell types and functions, cytokines and chemokines, and intracellular signaling mechanisms in immune cells
  • Strong organizational and communication skills
  • Experience with data analysis software packages like GraphPad Prism or equivalent
  • Excellent work ethic displayed as a reliable, self-motivated, enthusiastic team player who can prioritize and balance multiple projects and tasks
  • Good manual dexterity

Physical Demands

  • Occasional lifting to 30 pounds
  • Fine motor movements in fingers/hands to operate computers, other office equipment, repetitive motion with lab equipment
  • Repetitive motion work in the lab

Position Type/Expected Hours of Work

  • This is an essential job and expected to report for work regardless of weather and/or other conditions
  • Occasional evening and weekend hours required
  • This role is currently working onsite and is expected to work onsite for the majority of working hours. The primary work location for this role is 615 Westlake Ave N., with flexibility to work remotely on a limited basis.

Additional Eligibility Qualifications

  • In keeping with our focus on employee safety, all employees must be fully vaccinated against COVID-19 as a condition of employment unless a medical or religious exemption is approved. All employees will be required to keep their vaccination status up to date according to CDC guidance and our policy.

Additional Comments

  • **Please note, this opportunity offers relocation assistance**
  • **Please note, this opportunity offers work visa sponsorship**

It is the policy of the Allen Institute to provide equal employment opportunity (EEO) to all persons regardless of age, color, national origin, citizenship status, physical or mental disability, race, religion, creed, gender, sex, sexual orientation, gender identity and/or expression, genetic information, marital status, status with regard to public assistance, veteran status, or any other characteristic protected by federal, state or local law. In addition, the Allen Institute will provide reasonable accommodations for qualified individuals with disabilities.





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