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Research Associate I - Multi-modal Imaging and Histology

Department: Optical Physiology

Research Associate I - Multi-modal Imaging & Histology

 

The mission of the Allen Institute is to unlock the complexities of bioscience and advance our knowledge to improve human health. Using an open science, multi-scale, team-oriented approach, the Allen Institute focuses on accelerating foundational research, developing standards and models, and cultivating new ideas to make a broad, transformational impact on science.

The MindScope program seeks to understand the transformations, sometimes called computations, in coding and decoding that lead from photons to behavior and conscious experience by observing, perturbing and modeling the physical transformations of signals in the cortical-thalamic visual system within a few perception-action cycles.

This position is on a new, developing team within the Mindscope program that will use the instituteís multiplex fluorescence in situ hybridization (mFISH) platform.  In this role, the Research Associate I will be responsible for performing sample preparation, data collection, and data management for the mFISH-lightsheet pipeline.  As such, this role requires proficiency in modern bench techniques for tissue processing and the operation of fluorescence microscopy acquisition hardware.

The successful applicant will work closely with members of Mindscope program and Allen Institute for Brain Science, including bench scientists, microscopists, computational specialists and downstream data analysts.  This position serves as a critical role in ongoing Mindscope projects aimed at linking transcriptomic cell type identity to functional imaging data obtained from behaving mice. 

The Allen Institute believes that team science significantly benefits from the participation of diverse voices, experiences, and backgrounds. High-quality science can only be produced when it includes different perspectives. We are committed to increasing diversity across every team and encourage people from all backgrounds to apply for this role.

Essential Functions

  • Perform clearing and staining of fixed tissue using established in situ hybridization of RNA protocols
  • Prepare buffers and solutions for various tissue processing procedures
  • Prepare and mount tissue samples for fluorescence imaging
  • Operate a custom light sheet fluorescence microscope via MicroManager control and acquisition software
  • Maintain accurate and detailed laboratory documentation including lab notebooks, data acquisition and quality control records

Note: Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions. This description reflects managementís assignment of essential functions; it does not proscribe or restrict the tasks that may be assigned.

Required Education and Experience

  • Bachelors Degree in biology, biochemistry, neuroscience, or other related field
  • Proficiency in MS Office

Preferred Education and Experience

  • Experience with tissue staining techniques such as in situ hybridization or immunolabeling.
  • Experience with microscope operation/data collection
  • 0-2 years experience in biological sample processing and/or microscopic data acquisition
  • Demonstrated ability to work collaboratively within interdisciplinary teams
  • Willingness to cross-train and perform other duties as assigned
  • Demonstrated ability to follow standard operating procedures and safety guidelines
  • Prior experience working in a high throughput environment.
  • Demonstrated experience in maintain RNase-free conditions and/or experience with aseptic techniques
  • Attention to detail and quantitative problem solving
  • Demonstrated ability to juggle and complete multiple tasks in a timely manner
  • Experience working with automated liquid handling platforms
  • Excellent interpersonal and communication skills

Work Environment

  • Laboratory environment including potential exposure to chemicals, biohazard tissue and operating automated lab equipment

Physical Demands

  • Fine motor movements in fingers/hands to manipulate delicate biological samples, position lab equipment, and operate computers
  • Stooping, bending, crouching
  • Reaching, or climbing ladders
  • Occasional exposure to safety hazards, noises, change in temperature, climbing and/or lifting (30+lbs), chemicals, and other hazardous materials and machinery
  • Exposure to Class IV lasers

Position Type/Expected Hours of Work

  • May be required to work alternate hours (ie, Saturday or Sunday shift) on occasion.
  • This is an essential job and expected to report for work regardless of weather and/or other conditions
  • Rotating weekend shifts
  • Rotating evening and weekend on-call coverage
  • Occasional evening and weekend hours required
  • This role is currently working onsite and remotely when possible, due to COVID-19 and our focus on employee safety. We continue to evaluate the safest options for our employees.

Additional Eligibility Qualifications

  • In keeping with our focus on employee safety, all employees must be up to date with vaccinations against COVID-19 as a condition of employment unless a medical or religious accommodation is approved. All employees will be required to keep their vaccination status up to date according to CDC guidance.

Additional Comments

  • Applicants are encouraged to include a cover letter noting all prior experience working in this type of environment which may or may not be from a clinical or scientific industry setting
  • **Please note, this opportunity does not sponsor work visas **
  • **Please note, this opportunity does not offer relocation assistance**

 

It is the policy of the Allen Institute to provide equal employment opportunity (EEO) to all persons regardless of age, color, national origin, citizenship status, physical or mental disability, race, religion, creed, gender, sex, sexual orientation, gender identity and/or expression, genetic information, marital status, status with regard to public assistance, veteran status, or any other characteristic protected by federal, state or local law. In addition, the Allen Institute will provide reasonable accommodations for qualified individuals with disabilities.

 

 

 
 
 
 

 

 
 

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