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Department: | Human Cell Types |
Scientist II – AAV Gene Therapy – Therapeutic Lead
The mission of the Allen Institute for Brain Science is to accelerate the understanding of how the human brain works in health and disease. Using a big science approach, we generate useful public resources, drive technological and analytical advances, and discover fundamental brain properties through integration of experiments, modeling and theory.
We are seeking a scientist to join the gene therapy program at the Allen Institute for Brain Science. This program aims to develop and test new therapeutic AAVs to treat brain disorders including severe forms of epilepsy and other neurodevelopmental diseases using a novel AAV-based cell type-specific expression system. We are seeking a scientist with a strong background in neuroscience, models of neurological diseases, and molecular and cellular biology. We are particularly interested in scientists with strong backgrounds in genetic forms of epilepsy and intellectual disability, and generating therapeutic strategies to treat those disorders.
The scientist will lead efforts to build and validate new AAV-based therapeutics for a particular epileptic neurodevelopmental disorder. This scientist will be the intellectual lead for this disease and will be expected to become a domain expert for current state of the art in that field. They will lead therapeutic AAV design and construction, establishing cell-culture based and in vivo assays to measure a functional response to the vectors and establishing efficacy. This scientist will also lead experiments to establish vector safety and biodistribution. They will also be responsible for prompt and accurate reporting of data to the group and external collaborators. This individual must have a strong track record and be excited by the prospect of joining a team-science environment at the Allen Institute for Brain Science to help develop new gene therapies for brain diseases.
The Allen Institute believes that team science significantly benefits from the participation of diverse voices, experiences and backgrounds. High-quality science can only be produced when it includes different perspectives. We are committed to increasing diversity across every team and encourage people from all backgrounds to apply for this role.
Essential Functions
Note: Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions. This description reflects management’s assignment of essential functions; it does not proscribe or restrict the tasks that may be assigned.
Required Education and Experience
Preferred Education and Experience
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Additional Comments
It is the policy of the Allen Institute to provide equal employment opportunity (EEO) to all persons regardless of age, color, national origin, citizenship status, physical or mental disability, race, religion, creed, gender, sex, sexual orientation, gender identity and/or expression, genetic information, marital status, status with regard to public assistance, veteran status, or any other characteristic protected by federal, state or local law. In addition, the Allen Institute will provide reasonable accommodations for qualified individuals with disabilities.