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Human Cell Types Intern - Human variation in cortical cell types

Department: 2520- Human Cell Types
Location: Seattle


Human variation in cortical cell types

Project Overview:

There are on the order of 100 cell types in human temporal cortex that are defined by patterns of gene expression. These cell types appear to be relatively conserved across human individuals, but there are likely to be important differences that are associated with age, genetic background, or other variables. We have collected whole-genome sequencing and single nucleus RNA-seq data from many human donors who have undergone brain surgery for intractable epilepsy or tumor resection. This project aims to quantify how cell type gene expression differs across human individuals and if any donor characteristics can explain this variation. First, it will require collecting and organizing the demographic, clinical, and genomic information about these neurosurgical donors and identifying major axes of variation. Second, it will require analyzing differences in cell type frequency and expression across individuals. Finally, it will involve testing for associations between donor characteristics and cell type variation.

Educational Objectives:

  • Identify major axes of variation among characteristics of neurosurgical donors
  • Learn to analyze whole-genome sequencing and compare genomic sequence across individuals
  • Review cellular diversity in human cortex
  • Learn to analyze single nucleus RNA-seq data and compare cell type expression across individuals


  • U.S. Citizen or U.S. Permanent Resident currently enrolled in an accredited U.S. college or university.
  • Enrolled in undergraduate studies or in a Masterís program. You must be enrolled and returning to school Fall quarter.
  • Must be able to start on either June 3rd or June 17th, 2019 and commit to the full 10-12 week internship time period. Interns will be expected to work 35-40 hours a week.
  • Must be 18 years of age or older.


Interns will receive $15.00 per hour which is equivalent to $6,000 less taxes.


Housing is not provided as a part of the internship program. If selected we will provide a list of housing resources for you.


Interns will be provided with an ORCA business passport free of charge for the duration of their internship.

How to Apply

  1. Complete an application through this portal. The application deadline is January 30, 2019.
  2. Submit a resume as well as the following documents using the + supplemental documents button:
    • A personal statement describing your interest in Allen Institute for Brain Science
    • College transcript with Cumulative GPA and Courses taken (can be unofficial)

3. Send one letter of recommendation to

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