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Electrophysiology Intern - ion channel properties

Department: 2380-Electrophysiology
Location: Seattle

Title:

Understanding how ion channel properties relate to physiological and genetic characterization.

Project Overview:

We aim to understand how the physiology, morphology, and gene expression profile of each neuron relates to one another and different cell classes within the brain. We have optimized a technique, Patch-seq, that allows for the large-scale characterization of these three modalities from thousands of individual mouse and human neurons. For a subset of neurons, in addition to intrinsic electrical properties (like the kinetics of action potential firing), we can probe the magnitude and behavior of ion channel proteins through voltage clamp experiments. This project will focus on analyzing the ion channel currents from these cells, and identifying key features (electrophysiological and transcriptomic) that can be attributed to individual ion channel types.

Educational Objectives:

  • Gain an understanding of the basic biophysical properties of cellular neuroscience
  • Utilize data science tools (Python and SQL) to synthesize and clean raw, large-scale data from multiple sources
  • Analyze and discover patterns in pre-computed features, with opportunities for engineering original features that could provide novel insights
  • Build experience with multidisciplinary team-driven projects.

Eligibility

  • U.S. Citizen or U.S. Permanent Resident currently enrolled in an accredited U.S. college or university.
  • Enrolled in undergraduate studies or in a Masterís program. You must be enrolled and returning to school Fall quarter.
  • Must be able to start on either June 3rd or June 17th, 2019 and commit to the full 10-12 week internship time period. Interns will be expected to work 35-40 hours a week.
  • Must be 18 years of age or older.

Compensation

Interns will receive $15.00 per hour which is equivalent to $6,000 less taxes.

Housing

Housing is not provided as a part of the internship program. If selected we will provide a list of housing resources for you.

Transportation

Interns will be provided with an ORCA business passport free of charge for the duration of their internship.

How to Apply

  1. Complete an application through this portal. The application deadline is January 30, 2019.
  2. Submit a resume as well as the following documents using the + supplemental documents button:
    • A personal statement describing your interest in Allen Institute for Brain Science
    • College transcript with Cumulative GPA and Courses taken (can be unofficial)

3. Send one letter of recommendation to HR@alleninstitute.org.

Contact us

If you have any further questions please contact us at HR@alleninstitute.org.

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