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Scientist I - AAV Gene Therapy - Electroencephalography

Department: Human Cell Types
Location: Seattle

Scientist I – AAV Gene Therapy – Electroencephalography


The mission of the Allen Institute is to unlock the complexities of bioscience and advance our knowledge to improve human health. Using an open science, multi-scale, team-oriented approach, the Allen Institute focuses on accelerating foundational research, developing standards and models, and cultivating new ideas to make a broad, transformational impact on science.

The mission of the Allen Institute for Brain Science is to accelerate the understanding of how the human brain works in health and disease. Using a big science approach, we generate useful public resources, drive technological and analytical advances, and discover fundamental brain properties through integration of experiments, modeling and theory.

We are seeking a Scientist to join the gene therapy program at the Allen Institute for Brain Science.  This program aims to develop and test new therapeutic AAVs to treat brain disorders including severe forms of epilepsy and other neurodevelopmental diseases using a novel AAV-based cell type-specific expression system. We are seeking a scientist to help characterize the rescue of our candidate AAV therapeutics using electroencephalography (EEG). This scientist will be responsible for design, execution, and analysis of EEG experiments in multiple models of several developmental neurological diseases, including epilepsy. In this role, the scientist will also be responsible for prompt and accurate reporting of data to the group and external collaborators. This individual must have a strong track record and be excited by the prospect of joining a team-science environment at the Allen Institute for Brain Science to help develop new gene therapies for brain diseases.

The Allen Institute believes that team science significantly benefits from the participation of diverse voices, experiences and backgrounds. High-quality science can only be produced when it includes different perspectives. We are committed to increasing diversity across every team and encourage people from all backgrounds to apply for this role.

Essential Functions

  • Establish experimental design of EEG experiments to measure epileptic phenotypes in mouse models of neurological disease
  • Conduct surgeries to implant EEG, EMG, and ECG electrodes
  • Analyze EEG, EMG, and ECG data from mice
  • Conduct additional behavioral experiments for detailed analysis of disease model, and therapeutic AAV-mediated rescue
  • Rapid and transparent communication of all results
  • Take on complex problems and construct novel solutions in a timeline, milestone-driven and team-centric environment
  • Presentation of results internally, externally and through publications
  • Coordinate with commercial partners on in vivo EEG experiments

Note: Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions. This description reflects management’s assignment of essential functions; it does not proscribe or restrict the tasks that may be assigned.

Required Education and Experience

  • PhD or equivalent combination of degree and experience in neurobiology, developmental biology or related life sciences fields
  • Experience in MS Office programs and other relevant software programs (eg. EEG analysis software, image analysis software, etc.)

Preferred Education and Experience

  • PhD and 3-5 years experience in neurobiology, epilepsy, neurodevelopmental biology, or related fields
  • Experience conducting EEG to measure disease epilepsy phenotypes
  • Experience with mouse models of neurodevelopmental diseases
  • Experience with small animal surgery to implant electrodes
  • Experience with EEG data analysis
  • Highly motivated researcher, comfortable independently solving problems and establishing new procedures and processes.
  • Excellent organizational and communication skills
  • Experience leading projects, designing research projects, and mentoring others
  • Strong publication record

Work Environment

  • Exposure and handling of laboratory animals required
  • Possible exposure to BioSafety Level 2 organisms, such as recombinant viruses
  • Laboratory atmosphere - possible exposure to chemical, biological or other hazardous substances

Physical Demands

  • Occasional lifting to 30 pounds
  • Fine motor movements in fingers/hands to operate computers and other office equipment; lab equipment
  • Frequently required to sit, stand, walk, stoop, kneel or reach

Position Type/Expected Hours of Work

  • This role is currently working onsite and remotely when possible, due to COVID-19 and our focus on employee safety. We continue to evaluate the safest options for our employees.
  • This position is funded through a sponsored research collaboration

Additional Comments

  • **Please note, this opportunity offers relocation assistance**
  • **Please note, this opportunity offers work visa sponsorship**


It is the policy of the Allen Institute to provide equal employment opportunity (EEO) to all persons regardless of age, color, national origin, citizenship status, physical or mental disability, race, religion, creed, gender, sex, sexual orientation, gender identity and/or expression, genetic information, marital status, status with regard to public assistance, veteran status, or any other characteristic protected by federal, state or local law. In addition, the Allen Institute will provide reasonable accommodations for qualified individuals with disabilities.





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