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Research Associate I – AAV Gene Therapy – Molecular Biology

Department: Human Cell Types
Location: Seattle

Research Associate I – AAV Gene Therapy – Molecular Biology

 

The mission of the Allen Institute is to unlock the complexities of bioscience and advance our knowledge to improve human health. Using an open science, multi-scale, team-oriented approach, the Allen Institute focuses on accelerating foundational research, developing standards and models, and cultivating new ideas to make a broad, transformational impact on science.

The mission of the Allen Institute for Brain Science is to accelerate the understanding of how the human brain works in health and disease. Using a big science approach, we generate useful public resources, drive technological and analytical advances, and discover fundamental brain properties through integration of experiments, modeling, and theory.

We are seeking a Research Associate I to join the Human Cell Types team. This candidate will work to identify and develop functional tools for CNS-targeting viral vector development. The tools to be discovered are functional elements of the genome that are being discovered from inspection of large-scale sequencing projects, and these elements will be cloned into vectors to directly assess their function.  Eventually, these elements will be used in vectors to support both experimentation in basic science, as well as application for therapeutic indications.

The candidate will join a small but dedicated team that is focused on the development of these viral vectors. The successful candidate will be a hard worker who strives for excellence, shows attention to detail, and can communicate effectively with both verbal and written lab documentation. He/she will also demonstrate an ability to complete tasks within tight deadlines.

The Allen Institute believes that team science significantly benefits from the participation of diverse voices, experiences, and backgrounds. High-quality science can only be produced when it includes different perspectives. We are committed to increasing diversity across every team and encourage people from all backgrounds to apply for this role.

Essential Functions

  • Standard molecular biology techniques including
    • PCR
    • Cloning
    • Sequence design
    • Primer design
    • Sanger sequencing
    • Restriction analysis
    • Gel electrophoresis
    • Miniprep DNA preparation from bacteria
    • Maxiprep DNA preparation from bacteria
    • Quantitative PCR
  • Working with AAVs
    • AAV design and cloning
    • AAV production
    • AAV transduction
  • Tissue analysis
    • Immunohistochemistry
    • mFISH
    • qRT-PCR
    • RNA sequencing

Note: Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions. This description reflects management’s assignment of essential functions; it does not proscribe or restrict the tasks that may be assigned.

Required Education and Experience

  • Bachelor’s degree in a life science or other related field

Preferred Experience

  • 0-2 years experience in a laboratory or research environment
  • Experience handling tissues from animals or human specimens
  • Familiarity with standard data reporting software (Microsoft Office)

Work Environment

  • Exposure and handling of laboratory animals required
  • Possible exposure to BioSafety Level 2 organisms, such as recombinant viruses
  • Laboratory atmosphere - possible exposure to chemical, biological or other hazardous substances

Physical Demands

  • Fine motor movements in fingers/hands to operate computers and other office equipment; lab equipment
  • Frequently required to sit, stand, walk, stoop, kneel or reach
  • Occasional lifting to 30 pounds

Position Type/Expected Hours of Work

  • This role is currently working onsite and remotely when possible, due to COVID-19 and our focus on employee safety. We continue to evaluate the safest options for our employees
  • This position is funded through a sponsored research collaboration

Additional Comments

  • **Please note, this opportunity does not sponsor work visas or provide relocation assistance**

 

It is the policy of the Allen Institute to provide equal employment opportunity (EEO) to all persons regardless of age, color, national origin, citizenship status, physical or mental disability, race, religion, creed, gender, sex, sexual orientation, gender identity and/or expression, genetic information, marital status, status with regard to public assistance, veteran status, or any other characteristic protected by federal, state or local law. In addition, the Allen Institute will provide reasonable accommodations for qualified individuals with disabilities.

 

 
 

 

 
 

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