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Research Associate I - AAV Gene Therapy - InVivo Testing

Department: Human Cell Types
Location: Seattle

Research Associate – AAV Gene Therapy – In Vivo Testing

The mission of the Allen Institute is to unlock the complexities of bioscience and advance our knowledge to improve human health. Using an open science, multi-scale, team-oriented approach, the Allen Institute focuses on accelerating foundational research, developing standards and models, and cultivating new ideas to make a broad, transformational impact on science.

The mission of the Allen Institute for Brain Science is to accelerate the understanding of how the human brain works in health and disease. Using a big science approach, we generate useful public resources, drive technological and analytical advances, and discover fundamental brain properties through integration of experiments, modeling and theory.

We are seeking a Research Associate to join the gene therapy program at the Allen Institute for Brain Science.  This program aims to develop and test new therapeutic AAVs to treat brain disorders including severe forms of epilepsy and other neurodevelopmental diseases using a novel AAV-based cell type-specific expression system. We are seeking a Research Associate with experience in neuroscience, fluorescence imaging and behavioral testing to support our in vivo therapeutic AAV testing. This Research Associate will join a growing team focused on gene therapies and work directly with other team members to execute critical time-sensitive experiments. This Research Associate must have exceptional organizational and communication skills.

The Allen Institute believes that team science significantly benefits from the participation of diverse voices, experiences and backgrounds. High-quality science can only be produced when it includes different perspectives. We are committed to increasing diversity across every team and encourage people from all backgrounds to apply for this role.

Essential Functions

  • Conduct experiments to measure RNA and protein expression in brain using IHC, mFISH, and fluorescence microscopy
  • Conduct image analysis and quantification
  • Synthesize data into displays and presentation easily reviewed by the team
  • Phenotypic evaluation of animal model(s) of human neurological diseases
  • Proactive problem-solving including initiating and maintaining dialog with outside vendors
  • Maintain detailed and precise records of all experiments
  • Rapid and transparent communication of all results
  • Ability to work on tight deadlines and work effectively in a team environment

Note: Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions. This description reflects management’s assignment of essential functions; it does not proscribe or restrict the tasks that may be assigned.

Required Education and Experience

  • BS or BA in neurobiology, cell biology, biology, biochemistry or related fields
  • Proficient in MS Office programs

Preferred Education and Experience

  • BA/BS with 1-2 years research experience in neurobiology, virology, or related fields
  • Experience with phenotypic testing animal models of epilepsy or other neurodevelopmental diseases
  • Experience sectioning and staining mouse brain tissues
  • Experience imaging tissues with fluorescence microscopy
  • Image analysis and quantification experience
  • Experience with quantitative-PCR
  • Excellent organizational and communication skills

Work Environment

  • Exposure and handling of laboratory animals required
  • Possible exposure to BioSafety Level 2 organisms, such as recombinant viruses
  • Laboratory atmosphere - possible exposure to chemical, biological or other hazardous substances

Physical Demands

  • Occasional lifting to 30 pounds
  • Frequently required to sit, stand, walk, stoop, kneel or reach
  • Fine motor movements in fingers/hands to operate computers and other office equipment; repetitive motion wth lab equipment

Position Type/Expected Hours of Work

  • This role is currently working onsite and remotely when possible, due to COVID-19 and our focus on employee safety. We continue to evaluate the safest options for our employees
  • This position is funded through a sponsored research collaboration

Additional Comments

  • **Please note, this opportunity does not sponsor work visas or offer relocation**


It is the policy of the Allen Institute to provide equal employment opportunity (EEO) to all persons regardless of age, color, national origin, citizenship status, physical or mental disability, race, religion, creed, gender, sex, sexual orientation, gender identity and/or expression, genetic information, marital status, status with regard to public assistance, veteran status, or any other characteristic protected by federal, state or local law. In addition, the Allen Institute will provide reasonable accommodations for qualified individuals with disabilities.





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