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Assistant Investigator - Human Gene Therapy

Department: Human Cell Types
Location: Seattle

Assistant Investigator - Human Gene Therapy


The Allen Institute for Brain Science, located in Seattle, Washington, is comprised of a multidisciplinary staff committed to understanding how the brain works and helping to unlock the mysteries of neurological diseases and disorders affecting millions worldwide. Using an open science, multi-scale, team-oriented approach, the Allen Institute focuses on accelerating foundational research, developing standards and models, and cultivating new ideas to make a broad, transformational impact on science.

We have recently begun a gene therapy program that builds on our pioneering characterization of brain cell types to develop and test new therapeutic AAVs to treat brain disorders by targeting specific cell types.  We seek an outstanding individual to lead research efforts in multiple neurodevelopmental and/or neurodegenerative disorders, working in a team environment to take tools and knowledge developed in the basic research arm of the Institute to preclinical studies aimed to advance candidate vectors towards clinical applications.

The successful candidate will have a strong background in gene therapy-related applications in academia or industry, preferably with expertise in neurodevelopmental and neurodegeneration-related diseases.   We seek an individual with a track record of both individual and team contributions in solving complex research problems, and experience in cutting edge viral vector technologies and animal model preclinical studies.  This is a multidisciplinary project requiring knowledge of AAV-based gene therapy applications, modern single cell -omics methods, animal model behavioral studies, biodistribution and toxicology studies.  Strong preference will be given to candidates that bring expertise in advancing candidate therapeutic vectors through IND-enabling studies.

Reporting to the Director of the Human Cell Types Department at the Allen Institute for Brain Science, the ideal candidate is a self-motivated team player who is willing to push the boundaries of human gene therapy research through scientific leadership, individual and team contributions and continuing scholarship in this ever-changing landscape. The candidate should have management experience and will be expected to help recruit and build a team of top caliber scientists and research associates. The successful candidate will also have excellent communication skills that can represent our efforts to our stakeholders internally and in external forum.

The Allen Institute offers exceptional working conditions, and nurtures team science in an intellectually rich and stimulating setting. We provide a highly collaborative research environment offering the opportunity to interface closely with our molecular and cell biologists, bioinformaticians, and academic and industry partners. This is a Principal Investigator position similar to an Assistant Professor in a University/Medical School setting. The successful candidate will have demonstrated research productivity and is in early stages of defining and implementing an independent research program. The candidate should have publications in relevant peer-reviewed scientific journals.

The Allen Institute believes that team science significantly benefits from the participation of diverse voices, experiences, and backgrounds. High-quality science can only be produced when it includes different perspectives. We are committed to increasing diversity across every team and encourage people from all backgrounds to apply for this role.

Essential Functions

  • Lead the research to solve complex AAV-based gene therapy research problems
  • Lead the design of AAV-based gene therapy applications
  • Regularly present data (in oral and/or written form) to the internal and external research communities.
  • Lead the collaborative efforts with other scientific and management teams in data generation and analysis
  • Will lead and directly participate in team recruitment activities

Required Education and Experience

  • Ph.D. and/or M.D. in neuroscience, biology, physics, engineering, or related academic or biomedical discipline; or equivalent combination of degree and experience
  • 5 or more years of post-PhD working experience in academia or industry in brain disease research, including gene therapy-related research
  • Experience and technical knowledge of AAV-based gene therapy applications, preclinical animal model studies, and IND-enabling studies with supporting publication record
  • Experience managing scientific teams
  • Proven strong written and verbal communication skills
  • Excellent management skills and ability to work in a group and interact closely with experimentalists and computational biologists

Preferred Education and Experience

  • Direct experience in neurodevelopmental or neurodegenerative disease gene therapy, and/or disease modeling and circuit dissection of behavior
  • Proven ability to drive IND-enabling preclinical studies
  • Able to work independently as well as in a collaborative high paced environment
  • Experience working with outside collaborators to achieve defined objectives
  • Ability to meet aggressive timelines and deliverables

Physical Demands

  • Fine motor movements in fingers/hands to operate computers and other office equipment

Position Type/Expected Hours of Work

  • This role is currently able to work remotely due to COVID-19 and our focus on employee safety. We are a Washington State employer, and remote work must be performed in Washington State. We continue to evaluate the safest options for our employees. As restrictions are lifted in relation to COVID-19, this role will return to work onsite.

Additional Comments

  • **Please note, this opportunity offers relocation assistance**
  • **Please note, this opportunity offers work visa sponsorship**


It is the policy of the Allen Institute to provide equal employment opportunity (EEO) to all persons regardless of age, color, national origin, citizenship status, physical or mental disability, race, religion, creed, gender, sex, sexual orientation, gender identity and/or expression, genetic information, marital status, status with regard to public assistance, veteran status, or any other characteristic protected by federal, state or local law. In addition, the Allen Institute will provide reasonable accommodations for qualified individuals with disabilities.





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