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Assistant Investigator, Alzheimer’s Disease Research

Department: 2520 - Human Cell Types
Location: Seattle

Assistant Investigator, Alzheimer’s Disease Research

Our mission at the Allen Institute is to advance our understanding of how the brain works in health and disease. Using a team science approach, we strive to discover how the brain implements fundamental computations through the integration of technological innovation, cutting-edge experiments, modeling, and theory.

The Allen Institute for Brain Science, located in Seattle, Washington, recently begun a major consortium program to understand the cellular and molecular basis of Alzheimer’s disease using cutting-edge single cell methods established at the Allen Institute and through the NIH BRAIN Initiative.  We are seeking an outstanding individual to lead computational data analysis efforts with the overarching goal of contributing to a deep mechanistic understanding of Alzheimer’s pathology and new cellular and molecular targets for therapeutic diagnosis and intervention.

The successful candidate will have a strong background in computational biology, with preferable experience in Alzheimer’s or other neurological or neurodegenerative diseases.  Strong preference will be given to individuals with a track record of both individual and team contributions in solving complex research problems, and experience in cutting edge computational methodologies applied to biological -omics, spatial and/or clinical metadata.  This is a multidisciplinary project requiring knowledge of the principal data types used for quantitative single cell analysis in modern neuroscience or cell biology, including single cell transcriptomics, epigenomics, and spatial transcriptomics, as well as quantitative neuropathology and clinical metadata.  By applying techniques from machine learning, computational analysis,  and related fields, and through a strong interfacing with key experimentalists, this investigator will play a strong role in generating a computation models and a framework for understanding the cellular and molecular locus of Alzheimer’s disease progression.

Reporting to the Director of the Human Cell Types Department at the Allen Institute for Brain Science, the ideal candidate is a self-motivated team player who is willing to push the boundaries of human neurodegenerative disease research through scientific leadership, individual and team contributions and continuing scholarship on the ever-changing landscape. The successful candidate will also have excellent communication skills that can represent our efforts to our stakeholders internally and in external forum.

Allen Institute offers exceptional working conditions, and nurtures team science in an intellectually rich and stimulating setting. We provide a highly collaborative research environment offering the opportunity to interface closely with our molecular and cell biologists, bioinformaticians, and partner institutions. This is a Principal Investigator position comparable to an Assistant Professor in a University/Medical School setting. The successful candidate will have demonstrated research productivity and is in early stages of defining and implementing an independent research program. The candidate should have publications in relevant peer-reviewed scientific journals.

Required Education and Experience

  • Ph.D. and/or M.D./Ph.D. in computational neuroscience or biology, physics, engineering, or related academic or biomedical discipline
  • 5 or more years of post-PhD working experience in computational neuroscience or disease research
  • Experience and technical knowledge of neuroscience, computational modeling, and machine learning paradigms, with supporting publication record
  • Strong knowledge of systems, cellular and/or molecular neuroscience
  • Strong written and verbal communication skills
  • Ability to meet aggressive timelines and deliverables
  • Excellent management skills and ability to work in a group and interact closely with experimentalists

Preferred Education and Experience

  • Direct experience in human Alzheimer’s or related dementia research
  • Proven ability to drive meaningful data analyses and visualizations from very large datasets and work synergistically with bioinformaticians/systems biology teams
  • Able to work independently as well as in a collaborative high paced environment
  • Experience working with outside collaborators to achieve defined objectives
  • Familiarity with other external AD research efforts such as SAGE Bionetworks and ROSMAP

It is the policy of the Allen Institute to provide equal employment opportunity (EEO) to all persons regardless of age, color, national origin, citizenship status, physical or mental disability, race, religion, creed, gender, sex, sexual orientation, gender identity and/or expression, genetic information, marital status, status with regard to public assistance, veteran status, or any other characteristic protected by federal, state or local law. In addition, the Allen Institute will provide reasonable accommodations for qualified individuals with disabilities.

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