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Research Associate I - Molecular Genetics

Department: 2390- Molecular Genetics
Location: Seattle

Research Associate I Molecular Genetics

The mammalian brain contains a rich diversity of cell types that function in a highly organized and coordinated manner to influence behavior. Recent efforts to catalog neuronal cell types based on their transcriptional profiles within the mouse neocortex have revealed entirely new classes of cell types. To systematically profile their properties at a single cell level and probe their activity within a neural circuit in an awake behaving animal we need to create new genetic tools.

The Transgenic Technology team within the Molecular Genetics department aims to generate a large and diverse set of transgenic mouse lines and viruses for cell-type-specific investigations by building upon on our existing transgenic expression platforms and identifying enhancer elements from single cell epigenomics data. These genetic tools will enable the analysis of the structure and function of microcircuits within the brain and represent foundational resources for the neuroscience community. We seek an enthusiastic individual that will perform molecular cloning, histological methods, and cell culture work to support all aspects of our genetic tool development and characterization efforts.

Job Responsibilities

  • Generate viral (AAV) vectors and complex targeting vectors
  • Perform in vitro testing of newly generated vectors in heterologous cells
  • Generate AAV viruses and perform retroorbital injections into transgenic mice
  • Section fixed mouse brains and analyze transgene expression within the brain by performing immunohistochemistry, epifluorescence and confocal imaging
  • Perform general lab and organizational tasks to support team efforts
  • Maintain accurate and detailed electronic laboratory notebook records
  • Follow standard operation procedures and maintain good laboratory practices
  • Ability to work independently and within a collaborative, multi-disciplinary environment
  • Positive attitude, self-motivated, and ability to trouble-shoot
  • Outstanding communication skills and team player mentality

Required Qualifications

  • B.A., B.S., or M.S. in Neurobiology, Genetics, Biochemistry or related discipline
  • Experience working in a laboratory research environment
  • Proficiency with Microsoft Office software (Word, Excel, PowerPoint) required

Preferred Qualifications

  • Preferred 1+ years of experience working in a laboratory research environment
  • Experience with molecular cloning, cell culture techniques, AAV virus production and histology preferred
  • Knowledge of mouse genetics and genetic tool development a plus
  • Proficiency with recombinant DNA construction software (Geneious) and Adobe Software (Photoshop, Illustrator) preferred

It is the policy of the Allen Institute to provide equal employment opportunity (EEO) to all persons regardless of age, color, national origin, citizenship status, physical or mental disability, race, religion, creed, gender, sex, sexual orientation, gender identity and/or expression, genetic information, marital status, status with regard to public assistance, veteran status, or any other characteristic protected by federal, state or local law. In addition, the Allen Institute will provide reasonable accommodations for qualified individuals with disabilities.

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