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Scientist I AAV Viral Capsid Discovery

Department: 2520- Human Cell Types
Location: Seattle

Scientist I AAV Viral Capsid Discovery

We are seeking a PhD level scientist to join a new program at the Allen Institute for Brain Science to develop and test new therapeutic AAVs to treat brain disorders including severe forms of epilepsy using a novel AAV-based cell type-specific expression system. This person will lead efforts to generate or identify new AAV capsids to facilitate brain delivery of therapeutic AAV viral vectors in non-human primates and humans.

We are seeking a scientist with a background in the virology and neuroscience. They will be responsible for working on a collaborative team to conduct experiments designed to identify naturally occurring neurotropic AAVs from human tissue as well as screen for mutated AAV capsids that improve the efficiency of targeting neurons throughout the primate brain, and could be suitable for gene therapy applications. This individual must be excited by the prospect of joining a team-science environment at the Allen Institute for Brain Science to help develop new gene therapies for brain diseases.

Job Responsibilities

  • Develop experiments to identify naturally occurring AAV capsids.
  • Evaluate tropism/distribution of known and newly identified capsids.
  • Conduct in vivo selection screens to recover capsids with desired properties.
  • Oversee collaborative efforts to identify selective AAV capsids.
  • Rapid and transparent communication of all successes and failures.
  • Presentation of results internally, externally and through publications.
  • Must follow good laboratory practices.
  • Highly motivated researcher, comfortable operating independently.
  • Experience working in a timeline, milestone-driven, and team work environment is preferred.
  • Excellent organizational and communication skills.
  • Proficiency in MS Office programs.

Required Qualifications

  • PhD in virology, neurobiology, or related fields.
  • Experience with virus production and testing
  • 0-2 years post-doc expereince in a laboratory or research enviroment

It is the policy of the Allen Institute to provide equal employment opportunity (EEO) to all persons regardless of age, color, national origin, citizenship status, physical or mental disability, race, religion, creed, gender, sex, sexual orientation, gender identity and/or expression, genetic information, marital status, status with regard to public assistance, veteran status, or any other characteristic protected by federal, state or local law. In addition, the Allen Institute will provide reasonable accommodations for qualified individuals with disabilities.

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